First, I want to thank you for the time and effort that went into writing this article. I was unaware of MDR1 Mutation drug reactions at the time. (The Environmental Protection Agency is responsible for approving external flea and tick products.) Some remain safe, others should be avoided. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. I did not need to try the Seresto collar. (Theres also a hyperlink to her article.) The main goal of this medication, according to the FDA, is; The emphasis of this article will continue to be on safety, though I have no doubt as to the efficacy of certain pest preventives over others. Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. Hi Vicki, Could that have been the cause of the seizure, even though she took it more than a month ago? I just took her off Sentinel Flavor Tabs. As with any topical, of course keep an eye out for skin irritation. Also what can be used for giardia? Unless youre, say, an expat living in China, you can definitely find a better option. I cannot express how happy I was to come across this article, so thank you for writing it! The best thing about Seresto is how long it can do its job up to 8 months! Sugar is a great name for a Collie as they really are such sweethearts. Because of their similarity to Heartgard, Ive placed them in the same caution category. Somewhere I read that its good for 4 kinds. My border collie/lab mix has a major seizure yesterday and has no history of seizures before this. Best of luck! It is safe for use with anthelmintics like heartworm meds and has no known negative drug-drug interactions. If you think about it, come back here and let me and other readers know what worked best for you! new post updates in monthly email newsletters. She had a severe reaction with diarrhea, drooling, depression etc. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. Thank you for writing this article. Simparica TRIO. Review this. It was winter. Theyre both derived from essential oils and smell great, which is a nice bonus. I would actually place it in the caution category, since if a dog who had an active heartworm infection was given diethylcarbamazine (Dimmitrols main ingredient) it could suffer severe side effects and even die. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). Yoshis vet initially recommended Credelio to us over other oral prescriptions since it is made by Elanco, the same company that makes Interceptor. Our are both indoors and outdoors. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. We are waiting for the results from her test for the MDR1 gene. Simparica Trio proven to block the pathogen that causes Lyme disease by killing deer ticks . Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! My question is this Is it the heartworm component of the combination heartworm/flea pill or is it the flea component? What do you know about this? I found some good information on the Cyphenothrin in Parastar Plus in this article. Our dogs deserve the best. Simparica: The manufacturer of Simparica has tested the product for safety in dogs with the MDR1 . Simparica Trio should be given orally once a month at the recommended minimum doses: 0.54 milligrams of sarolaner, 0.011 mlilligrams of moxidectin, and 2.27 milligrams of pyrantel per pound of body weight. Thank you for the warning. Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. I hate to use anything, but also tired of keeping my dogs in a bubble. I appreciate the research in this thank you! . Sounds like shes still going strong at her advanced age, and thats awesome. Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. Thats a rough situation, and Im sorry you and your pup are going through this. THREE OF THE 8 FEMALES WENT INTO ESTRUS. His food hadnt changed, so Im nearly certain it was an adverse reaction to the Credelio. Simparica Trio Dosage. Thousands of dogs have experienced serious adverse reactions after taking . Doses used for heartworm prevention are safe to use in these breeds of dogs. (Bacon) 3.8 (6,612) $2691 ($0.19/Count) $24.22 with Subscribe & Save discount. I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. Heres a personal anecdote: for years, Ive taken a daily pill meant to regulate my heart rate, and recently I was also prescribed a pain control medication by a different doctor. I hope you get this. Natural Chemistry claims to kill on contact and to be safe for puppies. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. Is the Frontline the one listed in the article ok in a multi dog family where there is a risk of one licking it off the other? Dogs with the mutation lack a protein (P-glycoprotein) which is responsible for pumping the drugs from the brain. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. Ivermectin is reported safe at heartworm prevention doses but there are better drugs available. Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. (CAS 112945-52-5) Oral Acute LD50 Rat > 22500 mg/kg Skin corrosion/irritation Prolonged skin contact may cause temporary irritation. Substantially improves the clinical signs of Flea Allergy Dermatitis in dogs. (No judgment if you didnt see that section: I know its a very long article and I expect most people are looking for a quick or specific answer and dont actually read the whole thing ?.) Thanks much for the info before I bought anything! Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. I cant claim to have all the answers, and my goal with this article was simply to make a fairly comprehensive guide to help each pet owner make an informed decision in tandem with their veterinarian. What an awesome article. Waxman and Brooks both recommend it. Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. Still, if you live in the city and dont walk your dogs through long grass or woodsy areas, this could be a great choice for you. Giardia can be passed to and cause diarrhea in humans. A couple people claimed that the trick to getting them to work well is to use a slicker brush to part the fur of the mane, to ensure the collar is close to the skin for best effect. Simparica Trio is an all-in-one monthly chewable treatment for dogs. MDR1 FAQs. My border collie started having seizures (he was on Bravecto AND Sentinel) and the vet never said anything about the gene mutation. We often go on walks in the woods. I have a cat myself, so I appreciate the information. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. Simparica TRIO is a monthly chew with triple protection against the three biggest threats facing our dogs today - fleas and ticks, intestinal worms and deadl. I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. Simparica Trio treats and protects against harmful parasites. . I just picked out a beautiful tri color rough collie this morning! 4.11 Withdrawal period(s) Best of luck with your new girl! I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. However, it does claim to kill fleas on contact. The MDR1 mutation is believed to occur in approximately 50% of Australian Shepherds. While my pain levels went down, I noticed that my heart rate went up! The FDA issued an alert to owners and veterinarians and said it was requiring clearer labels on the products. Fleas were treated with effifax, active ingredient fipronil. ), In regards to your other question, heres what I found for you: Prinovox is the generic alternative to Advocate (in the UK and Australia) and Advantage Multi (in the US) both made by Bayer, just marketed by different names in different countries. I just had my vet mention the mdr1 gene today in passing. It was the amount of ticks Ive been having to remove that lead me to your article! Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! The benefits of Simparica. (Most vets are going to recommend to you the products they carry in stock, but you can order online from Chewy or pet pharmacies.) Thank you very much! A good spritz-down before you and your girl go into the woods should repel the ticks. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. Sentinel comes in a chewable pill form and protects against multiple internal parasites (heartworms, whipworms, hookworms, and roundworms) as well as the development of flea eggs. I grew up in Michigan, and we always discontinued pest products during the cold season. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. Unacceptable for me) He is MDR1 clear. Ive had success using Burts Bees ear rinse on my dogs. Thanks. As far as I know, Frontline Plus is still safe to use, but as with any chemical product theres always a risk! However, Ive had the best results with a medicated ear mite treatment prescribed by my veterinarian. Basically, the idea is that heartworms take a few months to develop anyway, so every few months you get your dog tested instead of merely annually and ONLY treat for heartworms if bloodwork reveals that your dog has contracted heartworms. I have to state the disclaimer that Im not a vet just someone who took a Research and Publishing class in college. Get new post updates in monthly email newsletters. This is typically due to a specific genetic mutation (MDR1) that makes them less able to tolerate high doses of ivermectin. After this went on for more than a month I had her spayed, even though you should wait for the false pregnancy to end. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. Is Simparica Trio safe for dogs with MDR1? From the standpoint of MDR1 dogs, it is safe. My question is about Capstar. He has been using Simparica Trio since it came out several years ago, which eliminates the need for an additional monthly heart guard chewable. . Appreciated!!! Personally I use Frontline Plus and supplement weekly with a Natural Chemistry spray as a repellent, but I understand that might not be ideal for everyone depending on their situations. . Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. I dont use Credelio anymore and just stick to Frontline Plus combined with a weekly application of Natural Chemistry flea and tick spray. Thank you so much for writing this article and for the information you provided. (For those who may be wondering, the mutant/normal designation means that a dog carries one copy of a gene and is a carrier, though not affected to the degree that a homozygous, or mutant/mutant, dog would be.) For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. Eur. Congratulations and good luck with your new dog! Thankfully he recovered but my vet tells me Interceptor Plus is safe and he must have ingested something on his walk. Thank you. Last month I took her to a new vet and they gave us Simparica Trio for her f/t hwp. . I follow this advice, since Im a safe-is-better-than-sorry person. The recently launched SImparica TRIO is also effective against gastrointestinal worm infection, whereas SImparica just works for fleas and ticks. Last year I used Frontline Plus with no issues. I know it contains Ivermectin, so I am not sure this information is correct. I am so excited. Options: 3 flavors. Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable-for protection against heartworm disease, ticks & fleas, roundworms & hookworms.. One chewable tablet provides month-long protection for all dogs over 8 weeks old and weighing 2.8 pounds or more. Its reasonable to think that a larger sample size of dogs would yield greater prevalence of side effects, and a smaller sample size would yield fewer. However, its technically safe so long as it isnt applied past the shoulder blades where your Collie could reach it. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. Thank you for the research and the detailed info on each product. 2022 Collie Chatter. Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. My personal veterinarian is now only marketing the Credelio, Interceptor, and Trifexis oral parasite medications. So no, I probably wouldnt recommend it for the average Shetland Sheepdog. Flea Treatment and Prevention In a wellcontrolled laboratory study, SIMPARICA TRIO began to kill fleas at Simparica Trio prevented microfilaremia in all dogs and was highly effective (97.2%) and significantly better than either Heartgard Plus (8.5%) or Interceptor Plus (35.9%) in preventing the development of the ZoeLA ML-resistant heartworm strain when administered for six consecutive months in this co I have a 20 month old smith Border Collie who is heterozygous for the MDR1 gene. Im trying to find out if this is safe for her. Do you know what the ingredients are in the medicated shampoo? The oral chew contains a specially optimised trio of ingredients for . The MDR1 test will determine if your pet is affected by a mutation in the MDR1 gene. Hope this helps! My personal veterinarian is MDR1-aware and only prescribes Interceptor (probably the safest heartworm med) and Credelio (an oral flea/tick medication alternative to Nexgard). Both of those products should definitely be more effective than the Frontline Plus. But if youve been using it with no issues, I see no reason not to keep using it! Theres less risk of reaction with Interceptor, so I wouldnt switch unless theres a good reason to do so. Several clinical trials funded by Zoetis published shortly after drug approval showed impressive results concerning safety and incidence of adverse effects in dogs. What do you think about Frontline Gold? Oh no! Thank you so much for writing this article!!! Hes just a puppy himself and was already started on Interceptor and Credelio. Please log in again. Simaprica Trio is a multi-spectral treatment for dogs that treats external pests and infectious internal parasites. Vectras brag is that it repels and kills fleas, five kinds of ticks, flies, mosquitoes, and mites; however, its use is not worth its risk. This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. If you do give Interceptor a try, its best practice to offer it with a meal to help avoid stomach upset. Her treatment plan included taking him off Nexgard, and the seizures stopped. I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. From the time that the collar went on the market in 2012 until 2020, the EPA (Environmental Protection Agency) received 1,698 reports of deceased pets. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water). Any thoughts on either of these? FDA-approved to block the pathogen that may cause Lyme disease by killing deer ticks. Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). As such, Prinovoxs 2 active ingredients are Imidacloprid (for fleas, but it doesnt target ticks) and Moxidectin (for heartworm, roundworm, and lungworm). Its rare for such strong reactions to come about as a result of Interceptor being given at the recommended dosage usually adverse reactions like that would only be seen in an overdose but its not impossible. Este perfect pentru caini! I just quote the ones who are knowledgeable about MDR1. Simparica Trio is well tolerated in dogs with a deficient multidrugresistance- protein 1 (MDR1 -/-) following single oral administration at 3 times the recommended dose 1 THE SIMPARICA TRIO RANGE INCREASING COMPLIANCE FROM 2 MONTHS PER YEAR TO 12 WITH VETPOST COULD INCREASE REVENUE BY 600% ivermectin, selamectin)? Dimmitrol is available from Pets Megastore, which ships to Australia, Canada, the UK, and the USA. It provides 100% protection from heartworm disease. According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. Unfortunately, the fleas are fighting back. I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! 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